boot - Can I Run Ubuntu from a USB Flash Drive on a Built PC with No Operating System?

I am building a PC without optical drives. Will I be able run Ubuntu from an USB flash drive?

My plan is to try out Ubuntu on my built PC using USB flash drive and then depending on how I much like Ubuntu; either installing Windows 10 onto my SSD with Ubuntu alongside/inside it, or just installing Ubuntu onto my SSD without Windows. Will my plan be easily possible?